What practice in sequencing samples helps minimize carryover in automation?

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Multiple Choice

What practice in sequencing samples helps minimize carryover in automation?

Minimizing carryover in automation relies on using a validated carryover testing plan and sequencing strategy. A validated plan provides objective methods to measure how much material is left behind between samples, defines acceptable carryover limits for each assay, and specifies the changes needed to keep contamination below those limits. The sequencing strategy then applies that plan in practice: it orders runs and inserts appropriate washes, blanks, or calibrators, and spaces samples to reduce the chance that residual material from one specimen affects the next. This approach is evidence-based and tailored to the instrument and assays, so it reliably lowers cross-sample contamination. Running calibrators between patient samples helps monitor performance but doesn’t address inherent carryover between patient specimens, and sequencing strictly by age or in a random order doesn’t target contamination risks.

Minimizing carryover in automation relies on using a validated carryover testing plan and sequencing strategy. A validated plan provides objective methods to measure how much material is left behind between samples, defines acceptable carryover limits for each assay, and specifies the changes needed to keep contamination below those limits. The sequencing strategy then applies that plan in practice: it orders runs and inserts appropriate washes, blanks, or calibrators, and spaces samples to reduce the chance that residual material from one specimen affects the next. This approach is evidence-based and tailored to the instrument and assays, so it reliably lowers cross-sample contamination.

Running calibrators between patient samples helps monitor performance but doesn’t address inherent carryover between patient specimens, and sequencing strictly by age or in a random order doesn’t target contamination risks.

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