Which statement best describes LIS reconciliation in the context of chain-of-custody?

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LIS reconciliation is the process of ensuring data consistency across the entire workflow by matching what the instruments produce with what the Laboratory Information System records, all tied to the sample identifiers. This guarantees that results are attributed to the correct patient and specimen, and that the audit trail accurately reflects the steps from collection through analysis to reporting. By comparing instrument data (result values, run IDs, timestamps) with LIS entries (patient ID, order ID, test code) and the sample labels, any mismatches are detected and investigated before finalization, preventing misattribution of results and preserving data integrity and traceability. It isn’t about recording clinician notes, isn’t something that’s optional during maintenance, and isn’t the process that sets barcodes.